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Purity First

Purity First

Have you ever stopped to ask where your vitamins come from? How pure they actually are?

This question is relevant to all vitamins, but especially to liposomes, which have a phenomenally high rate of absorption and, if impure, can do significant damage to bodily systems. For example, if liposomal vitamin inputs contain heavy metals, those metals will be deposited into the cells and mitochondria - the very parts of the body where chronic illness sufferers need the most help. (If the liposomal vitamins are true liposomes, are pure, and are of quality manufacture, the maximum benefit will be achieved.)

Case in point: over 90% of commercial vitamin C, including that delivered in IV clinics, comes from China. China supplement manufacture, ironically, takes place in areas that are among the most polluted in the world. What’s more, there are no rules requiring the country of origin be specified on retail supplements.

In fact, Chinese manufacturers have repeatedly been reprimanded by the FDA due to prevelence of heavy metal content in their vitamins sold on the American market. Therefore, consumers who are unaware of the origins of their vitamins stand a great chance of ingesting toxins that will actually degrade their health and well-being.

IVtoGo's Uncompromising Quality Standards:

The IVtoGo team's purity philosophy was borne out of unfortunate experience. While in the midst of intensive treatment for an illness, one of our team members was tested for heavy metals. The results were astounding. He had the highest amount of lead in his system of any patient tested over the 11-years of the clinic's existence. One supplement he had been taking, which was from China, was brought into an environmental lab for testing. It contained astronomical lead levels. Six months of chelation and detoxification protocols were required to reduce the lead levels to a point where he could return to work.

IVtoGo's vitamin therapies specifically designed to eliminate this risk. They are manufactured in the USA at cGMP certified facilities, which means the process and facilities are inspected by the FDA to ensure that sanitation, documentation, and batch records meet the highest standards.  As for ingredients, they are sourced from the European Union, America, and Japan, including the reputable Setria brand Glutathione.

All ingredients are then double tested for Lead, Cadmium, Mercury, and Arsenic - both before and after bottling. Additional tests ensure each batch is free of all pathogenic agents.

These measures far surpass what is necessary. But they that the highest quality ingredients go into our products, and rigorous pharmaceutical standards are maintained throughout the production process.

Free of Unwanted Additives:

IVtoGo and C-Max are formulated to be free of sugar, soy, solvents, and alcohol. Solvents such as ethanol are actually common practice in the liposome industry. We recognize the importance of avoiding these substances so as to maintain the integrity and purity of the delivery system, and maximize health outcomes for our customers.

Pharmaceutical Grade Glass Bottling:

Packaging is often an afterthought, but the truth is that pthalates and plasticizers can leech into supplements and disrupt crucial hormonal pathways in the body, and degrade the entire endocrine system. Thus, IVtoGo is bottled in clean pharmaceutical glass to prevent this. IV bags and drip lines, for their part, are invariably made of highly unstable plastics - a risk that is mitigated through the use of highly stable glassware.

Thorough Testing Procedures:

Unlike vitamins originating in countries such as China, IVtoGo products undergo thorough testing to ensure they meet cGMP standards, which provide an objective, measurable standard so that the consumer can be confident in the production and documentation standards of producers. Accordingly, as alluded to above, IVtoGo products are tested for the presence of lead, arsenic, cadmium, and all common pathogenic agents. Additionally, they are double-tested for vitamin identity, both before and after production of each run, to ensure the exact therapy advertised is the same therapy delivered with each dose.

No Ethanol in Liposome Formation:

IVtoGo leverages pure and natural liposome formation technology. They are structured purely in that they they don't require the use of ethanol in the formation process. This not only ensures a more stable and absorbable vitamin; it also eliminates a key toxicity concern from the product profile.

100% Non-GMO and Pleasing Taste:

Philosophically, IVtoGo believes human health is not achievable through genetic modification. Thus, all the ingredients used in IVtoGo and C-Max are 100% non-GMO. They also offer a pleasing taste, making it easy for individuals to incorporate them into their daily routines and therapy regimens.

In Sum:

Perhaps this blog post will convince the reader that investing in a health therapy must always also mean verifying that no harm will be done by the therapy itself - and that this is even more true in the case of liposomes. Regardless IVtoGo stands ready with products wherein purity will always come first, and with no exceptions.

For more information, email us at hello@ivtogo.com, or call (888) 462-4859.

Revolutionizing Emergency Medicine in an Age of Pandemics

Revolutionizing Emergency Medicine in an Age of Pandemics

Introduction

Pandemics can be caused by various pathogens, such as viruses, bacteria, or other microorganisms. The emergence of a new pandemic depends on numerous factors like mutations, transmission rates, human activities, and global health measures.

As the global community awaits these potential threats, it is crucial to be prepared with the most powerful therapies possible. Traditional intravenous (IV) vitamin drips have long been a popular method for providing therapeutic nutrients like Vitamin C, Glutathione (GSH), and B vitamins. However,  IVtoGo has changed the game, offering a more convenient, accessible, and efficient alternative to traditional IV drips.

IVtoGo: A Game-Changer in Nutrient Delivery

IVtoGo has provided a way around traditional IV drip method with a unique, drinkable supplement that provides all the benefits of IV therapy in a tasty, easy-to-consume drinkable supplement. It uses liposome encapsulation technology to deliver vitamins in a highly bioavailable form, ensuring maximum absorption and efficacy.

In light of preparedness, here's why IVtoGo is a preferable alternative to traditional IV drips:

1. Convenience: No more time-consuming visits to clinics or dealing with cumbersome equipment. With IVtoGo, the power of IV-equivalent vitamin cocktails - with every nutrient at appropriate dose and delivered in true, medical grade liposomes - is available in a single bottle, allowing you to consume it anytime, anywhere.

2. Shelf Stability: IVtoGo remains stable at room temperature for 18 months, making it a perfect addition to your emergency preparedness kit or travel essentials. You don't have to worry about storage conditions or clinic locations like you would with traditional IV drips.

3. Cost-Effectiveness: Each bottle of IVtoGo contains three IV-equivalent therapies, ensuring you get the optimal dosage of Vitamin C, GSH, and B vitamins. IVtoGo's liposome encapsulation technology allows for efficient absorption, delivering the nutrients directly to your cells for maximum benefits. Priced like a single IV therapy, IVtoGo saves the user hundreds of dollars compared to traditional IV infusions.

4. Great Taste: IVtoGo's delicious flavor ensures that you and your family will actually enjoy consuming it, making it an enjoyable part of your daily health routine - or therapeutic intervention - when needed.


Conclusion

IVtoGo is a groundbreaking innovation that has the potential to make a significant impact on therapeutic interventions in times of crisis. By offering a convenient, shelf-stable, and highly bioavailable alternative to traditional IV drips, IVtoGo empowers individuals and organizations to be self-reliant in the face of uncertainty. As we continue to navigate the contingencies and challenges of probable future pandemics, the importance of preparedness cannot be overstated. With IVtoGo, you have a powerful tool at your disposal, providing essential nutrients and IV-caliber therapy whenever - and wherever - it may be necessary.

For further information, reach out to us at hello@ivtogo.com.

The Enhancement of C-Max

C-Max Liposomes deliver ascorbate (vitamin C) and menadione (vitamin K3) at what researchers have found to be the optimal ratio for killing cancer: 100:1.

The Enhancement of C-Max

As a cancer-oriented product, C-Max has always heeded the best oncological vitamin C research available. And by "best," the focus points have always been twofold: 1) oncologocially significant therapeutic effect; and 2) safety to normal human physiology. C-Max has always utilized vitamins C and K3, as this combination is so well-suited to these objectives; as one oncology research team has put it,

[Vitamin C and K3 therapy]...“has attracted the attention of researchers for more than 20 years due to its unusual ability to kill cancer cells without affecting the viability of normal cells” (Semkova, et al., 2020).

While C-Max has always employed these two potent natural substances, an upgrade was necessary.

What will be different with it? Scores of studies have indicated that CK3 therapy is highly effective for killing a wide variety of cancer cell types. But in the past, C-Max leveraged a subset of CK3 therapies. This subset utilizes vitamin C, Alpha Lipoic Acid, (ALA) and vitamin K3. In this modality, ALA performs a function similar to that of K3. Both are redox cycling quinones that potentiate vitamin C. In short, they, when co-administered with vitamin C, kill cancer through the uniquely efficient process of autoschizis - a systematic degradation of cancer cell walls and organelles. 

Subsequent and ongoing research into autoschizis has found that K3 and vitamin C seem to stimulate greater cancer cell degradation, and thus provoke increased autoschizis, when given alone (without ALA) . Additionally, the lion's share of these studies have found that the greatest cancer killing effect occurs when the ratio of vitamin C to vitamin K3 administered is 100:1. In light of these findings, the new version of C-Max will be constituted with vitamin C and K3 only, and at the validated ratio of 100:1.

Of course, the differentiator with C-Max, beyond the vitamins that are used, is the delivery method. C-Max delivers C and K3 with highly absorbed liposomes. Compared to IV and traditional oral forms, liposomes possess many important advantages. For example, they provide a greater therapeutic timeframe, i.e., doses stay in circulation for a longer time period; they achieve better concentrations in the lymphatic system (where most immune cells reside and where solid cancers spread); and they attain up to 100-fold better absorption into human cells than non-liposome encapsulated vitamins.

Following the Science

The research that has guided the C-Max enhancement includes the following studies. For reference, these papers have been organized according to cancer type:

Bladder Cancer

[T24 Cell Line] Gilloteaux, Jacques, et al. "Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells." Ultrastructural pathology 25.3 (2001): 183-192.

Brain Cancer

Sumiyoshi A, Shibata S, Zhelev Z, Miller T, Lazarova D, Aoki I, Obata T, Higashi T, Bakalova R. Targeting Glioblastoma via Selective Alteration of Mitochondrial Redox State. Cancers (Basel). 2022 Jan 19;14(3):485. doi: 10.3390/cancers14030485. PMID: 35158753; PMCID: PMC8833725.

Despotović A, Mirčić A, Misirlić-Denčić S, Harhaji-Trajković L, Trajković V, Zogović N, Tovilović-Kovačević G. Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells. Oxid Med Cell Longev. 2022 Mar 23;2022:2998132. doi: 10.1155/2022/2998132. PMID: 35368869; PMCID: PMC8967583.

Sumiyoshi A, Shibata S, Zhelev Z, Miller T, Lazarova D, Zlateva G, Aoki I, Bakalova R. Pharmacological Strategy for Selective Targeting of Glioblastoma by Redox-active Combination Drug - Comparison With the Chemotherapeutic Standard-of-care Temozolomide. Anticancer Res. 2021 Dec;41(12):6067-6076. doi: 10.21873/anticanres.15426. PMID: 34848461.

Breast Cancer

Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells: Bajor M, Graczyk-Jarzynka A, Marhelava K, Kurkowiak M, Rahman A, Aura C, Russell N, Zych AO, Firczuk M, Winiarska M, Gallagher WM, Zagozdzon R. Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells. Antioxidants (Basel). 2020 Apr 16;9(4):320. doi: 10.3390/antiox9040320. PMID: 32316111; PMCID: PMC7222372.

[MFC7 Cell Line] Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

[MFC7 Cell Line] Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.

Colon Cancer

[Colon 26 Cell Line] Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

[Colon 26 Cell Line] Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.

A D'Odorico, G C Sturniolo, R F Bilton, A I Morris, I T Gilmore, R Naccarato, Quinone-induced DNA single strand breaks in a human colon carcinoma cell line., Carcinogenesis, Volume 18, Issue 1, Jan 1997, Pages 43–46, https://doi.org/10.1093/carcin/18.1.43

Leukemia

[Jurkat Cell Line] Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615.

Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib: Ivanova D, Zhelev Z, Lazarova D, Getsov P, Bakalova R, Aoki I. Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib. Anticancer Res. 2018 Mar;38(3):1407-1414. doi: 10.21873/anticanres.12364. PMID: 29491065.

[Jurkat Cell Line] CK3 kills cancer cells, leaving healthy cells intact: Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.

Liver Cancer

Verrax J, Cadrobbi J, Marques C, Taper H, Habraken Y, Piette J, Calderon PB. Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death. Apoptosis. 2004 Mar;9(2):223-33. doi: 10.1023/B:APPT.0000018804.26026.1a. PMID: 15004519.

Ovarian Cancer

Jacques Gilloteaux, H. Lee Lau, Ioulia Gourari, Deborah Neal, James M. Jamison, J.L. Summers, Apatone® induces endometrioid ovarian carcinoma (MDAH 2774) cells to undergo karyolysis and cell death by autoschizis: A potent and safe anticancer treatment, Translational Research in Anatomy, Volume 1, 2015, Pages 25-39, ISSN 2214-854X.

Prostate Cancer

Gilloteaux J, Jamison JM, Summers JL. Pro-oxidant treatment of human prostate carcinoma (DU145) induces autoschizis cell death: autophagosomes build up out of injured endomembranes and mitochondria. Ultrastruct Pathol. 2014 Oct;38(5):315-28. doi: 10.3109/01913123.2014.927404. Epub 2014 Jun 23. PMID: 24955925.

Tareen B, Summers JL, Jamison JM, Neal DR, McGuire K, Gerson L, Diokno A. A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy. Int J Med Sci. 2008 Mar 24;5(2):62-7. doi: 10.7150/ijms.5.62. PMID: 18392145; PMCID: PMC2288789.

General Cancer Studies

The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress: Ren X, Santhosh SM, Coppo L, Ogata FT, Lu J, Holmgren A. The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress. Free Radic Biol Med. 2019 Apr;134:350-358. doi: 10.1016/j.freeradbiomed.2019.01.037. Epub 2019 Jan 28. PMID: 30703479.

Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation: Kizhuveetil U, Omer S, Karunagaran D, Suraishkumar GK. Improved redox anti-cancer treatment efficacy through reactive species rhythm manipulation. Sci Rep. 2020 Jan 31;10(1):1588. doi: 10.1038/s41598-020-58579-2. PMID: 32005913; PMCID: PMC6994657.

Thank you for reading. Should you have any questions about the new C-Max release, feel free to email us at sales@ivtogo.com. We'll be glad to help!

 

*Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/ Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi: 10.21873/anticanres.14151. PMID: 32234885.